Neuron News

MIT Focuses on the Neurotech Industry

Thanks to the tip from Zack Lynch that a new program from the MIT Sloan School of Management is researching the neurotechnology industry by trying to understand why innovations and business are successful in the field.

Lead by Assistant Professor Jason Davis, the work will be taking a close look at case histories of existing business models. The broader goal is to better understand how emerging technologies develop in certain organizational business structures and environments. It’s not clear how results will be released in the future, but this work could possibly lead to a valuable guide for future neurotech entrepreneurs to develop business models that will most likely succeed in the nascent industry.

MIT’s NeuroTechnology Innovation Project :: [ VISIT ]

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Beware of the Neuroscience Revolution

Great strides are occurring in neuroscience and neurotechnologies, and the public must begin its global debate to pro-actively prepare and plan how we will deal with the potentially-horrifying scientific advances.

This is a bit of an exaggerated summary of the warning proposed by neurobiologist, James Olds, who is the director of the Krasnow Institute for Advanced Study at George Mason University, in his recent op-ed article in The Washington Times.

There is certainly a decent pace on the advancement of neurotechnology, particular in areas that are focused on healing the body due to neurological disorders and neuro-trauma. There is also a large, continuing effort from neurbiologists, physicists, and philosophers for deepening our understanding of brain function and figuring out just how the mind “thinks.” If neuroscience ever experiences a great leap forward in fundamental knowledge of the brain, much like physics experienced critical leaps with GalileoNewton, and Einstein and Companyand more Company, our society will likely be heavily affected… and it would not be clear what sort of positive or negative effects might occur just from this new, basic understanding.

And, with a complete fundamental physics, so to speak, of brain function will also come a major bound in advancements of directly integrated digital components with the brain and other neurotechnological devices. It is these sorts of potential developments that the public and policy makers would want to have some sort of firm grasp on–both in the scientific understanding as well as the ethical implications–before any unforeseen neurotechnology providing a broad negative impact on society becomes out of hand or out of control.

This new, basic understanding, however, has not yet arrived, and it is not sitting on the horizon.

Without doubt, it is certainly important that more people are aware of the ongoing developments in neuroscience and neurotechnology, so that that we may keep our ethical beliefs in check with the technological applications. However, it is also important that the neuroscience is not limited at this time, in a similar way stem cell research has been recently stifled. (Although, there is certainly an argument for this comparison that the current administration’s distaste for stem cell programs drove the wonderful successes of non-embryonic stem cell discoveries.) Because, the fact of the matter is that this deep neurological understand is still far off… the brain system is a complex system, and this nascent field must produce new, general fundamentals before it will be capable of modeling and predicting complete brain behavior.

Unless, of course, we are blessed with a “Neuro-Einstein,” we still have a lot of work to do.

“OLDS: Preparing for a neuroscience revolution” :: The Washington Times :: August 24, 2008 :: [ READ ]

James Olds Kransnow Blog [ VIEW ]

The President’s Council on Bioethics: Neuroethics [ VISIT]

“Decade of the Mind” :: Philosophy, Ethics and Humanity in Medicine vol 3 no. 7, February 20, 2008 by Manfred Spitzer :: [ READ ]

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Building the Neuron Network with some Quick Thinking

The 100 billion neurons in your head have interconnected into a vastly complex network, and these connections can change and evolve as you “think” and “learn.” Exactly how this network architecture is developed and even how individual connections are selected is not yet clear.


Image from PhysOrg.com

However, researchers from the Max Planck Institute for Neurobiology have experimentally verified that neurons have an even more efficient method for quickly selecting “good” connections from “maybe-not-so-good” connections, even before the critical synapse–the chemical controller that regulates communication between neurons–is fully developed.

The discovery shows that as an extension of a neuron (either a dendrite or axon) comes into contact with another neuron, a flood of calcium ions exchanges with the pair of cells and if certain thresholds are reached, then the growing connection will stick around long enough for a synapse to form; otherwise, it will retract and wiggle about growing into another direction.

The biological growth technique is observed to be quite efficient with “decision-making” for forming connections, in particular because synapse development can take much longer to complete. Even though the following article loosely suggests that this network connection technique “enables thinking,” it’s not necessarily the case that each time we have a “thought” that we are actually making a new, physical connection. Neural “learning” likely requires an evolution in the network structure, but our notion of “thinking” is likely related more to the patterns of electrical behavior in the existing network.

This work is also quite important for the future development of neurotechnological devices. For a pure neuron device to connect directly with a human brain, it will be required to have neurons living on the implanted device to grow extensions and interconnect directly with the subject brain… so, an understanding of how these connections develop and select one another will be absolutely vital for successful devices.

So, check out the following articles, and we’ll be following the important developments.

“Efficient technique enables thinking” :: PhysOrg.com :: August 19, 2008 :: [ READ ]

“A Role for Local Calcium Signaling in Rapid Synaptic Partner Selection by Dendritic Filopodia,”Christian Lohmann and Tobias BonhoefferNeuron, Vol 59, 253-260, 31 July 2008 [ READ ABSTRACT ]

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Cultured Rat Neurons Control Robot

Can several hundred thousand rat neurons living in culture control the movements of a mechanical robot? Apparently to some extent so far, as researchers, including Dr. Ben Whalley, at the University of Reading have created a working “rat-brain-controlled” robot.

The controlling unit is, however, much less than that of a full rat brain, but in many respects it is actually much more interesting and exciting: the controller is a dish of rat neurons growing and interconnecting on top of an electrode array, which records electrical activity as well as electrically stimulates the cultured neuron network, and this all sits in a temperature-controlled environment in the lab safely separated from the actual robot. Wireless technology transmits the electrical information to and from from the culture and a mobile block with wheels and sonar sensors.

The electrical signals are filtered through software into movement controls for the robot. When the robot bumps into a wall, the sonar returns a signal to the culture dish to provide electrical feedback to the network. To date, the research has created a moving robot, and the team is now working to “train” the living neural network to appropriately respond to its environment… i.e., “don’t bump into the wall when you hear it coming.”

The group is particularly interested in how their basic understanding of this neural network can create memories, and how it will respond to imposed degradations of the physical network. This may lead to further clues into the progression of neurological disorders, including Alzheimer’s and Parkinson’s. Even with the focus on medical advancements for human disease, this research program at Reading is extremely exciting as a pure application of neurotechnology by working to develop a direct neuron-computer interface, and their results will be quite useful for the broader technological advancement of neurotech devices.

“Rat-brain robot aids memory study” :: BBC News :: August 13, 2008 :: [ READ with VIDEO ]

“Rat brain-controlled robot to give important neurological insights” :: The Tech Herald :: August 13, 2008 :: [ READ ]

“A ‘Frankenrobot’ with a biological brain” :: asiaone News :: August 14, 2008 :: [ READ ]

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US Intelligence Reviews the Future Role of Neurotechnology

Today, the National Research Council released a 202-page report covering the current developments in research related to cognitive neuroscience, and provides extensive recommendations to the United States intelligence community on what issues and technologies should be closely monitored. The progress in this broad field is rapid, and the NRC clearly states that our intelligence efforts are at a disadvantage with a low number of qualified agents involved in analyzing developments and providing recommendations to decision makers.

The report was commissioned by the Defense Intelligence Agency to identify neurotechnologies that will develop within the next twenty years, with a particular focus on potential military applications and their implications.

Detailed analysis of current and future technologies for the detection of deception,neuropsychopharmacologyfunctional neuroimagingcomputational biology, anddistributed human-machine systems are covered in the extensive report. In addition, the ethical and cultural ramifications of these neurotechnologies are reviewed by the reporting team.

Although the report focuses on specific, yet mostly still speculative, technological advancements, it’s primary goal is to provide a guideline to help the intelligence community improve itself so that it may more effectively detect, monitor, and evaluate the developments at home and (more importantly) abroad. It seems to say–rather blatantly–that neurotechnology will be a critical player in the future of our world, and very possibly the future of our world-wide military environment, and that our intelligence agencies are currently poorly equipped from an academic level to nimbly deal with these technologies as they present themselves from other nations or even from terrorist organizations.

In other words, it is time to take neurotechnology very seriously and bring our intelligence community up to par–and hopefully surpass the level–with this developing field.

By covering the broad range of current estimates as to what forms of neurotechnologies might find their way into military operations, the report also appears to provide an overview of where this research could lead our society. Many of the applications are certainly not wholly appealing, and would certainly lead to a future world that might be even more scary to live in–in a much more subtle way–than that of the previous world of “duck-and-cover“.

In particular, a recent article written by Tom Burghardt for Global Research.ca , was a bit of a “freak-out” over DARPA‘s “mysterious” efforts of military applications of neuroscience, referred to as “operational neuroscience.” Neuron News optioned not to feature the article here as the author “preferred” to use too many “quotes” to emphasize “scary” words and “phrases.” The “article” also created quite a “flood” of blogging in the “anti-government” and “everyone-is-out-to-get-us” community, that we felt we should keep out of the fray at the time. (We also feel that we should relax on the “quotes”!)

There are serious implications of neurotechnologies, and many of them could result in situations very undesirable for the continued long-term success of our species. However, it is important that we approach the developments not as political scare-mongers, but as educated citizen scientists who may appreciate the potentials of the technologies, and understand them well enough that we might also appropriately evaluate their ethical implications.

“Uncle Sam Wants Your Brain” :: Wired :: August 13, 2008 :: [ READ ]

“Report: spies need to stay on top of neuroscience research” :: ars technia :: August 13, 2008 :: [ READ ]

“Brain will be battlefield of future, warns US intelligence report” :: The Guardian, UK :: August 13, 2008 :: [ READ ]

“Emerging Cognitive Neuroscience and Related Technologies” :: [ READ THE EXECUTIVE SUMMARY ] from The National Academies Press

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Carbon Nanotubes May Enhance Neurotechnology Device

Taking direct electrical measurements from a living brain and even from a single neuron cell requires an invasive connection between the localized electrochemical environment in the cell and a sharp, prickly, prodding metal stake of death.

An electrode might sound harmless, but it can take the form of a gigantic (in the reference frame of a tiny neuron) metallic (or other electrical conducting material) needle that could either damage living tissue, or be rejected by the hosting biological system and quickly bombarded in tissue to effectively disengage the pointy invader.


image courtesy PhysOrg.com

Recently, a collaboration lead by Edward Keefer from the University of Texas Southwestern Medical School, has discovered that coating these harmful–but, necessarily formed–electrical recording devices with the ever popular carbon nanotube is the neuron’s newest fuzzy best friend. The nanotubues act to not only enhance the transmitted signals received from directly implanted electrodes, but they have been shown to be bio-compatible, so that they might even minimize the damage caused to the specimen. In fact, Keefer claims the efficiency of the cell-electrode interface is improved by at least one-thousand times.

The development of neurotechnological devices–hardware that interconnects directly with nervous tissue and even individual neurons–is absolutely dependent on not only the production of electrical connections that will result in highly sensitive signal transmission, but the cells will must also like to have these needles sticking around. The carbon nanotube coating approach could be a critical step in advancing neurotechnology to a future level of high-res recording devices as well as localized, highly-controllable stimulus systems.

“Carbon Nanotube-Coated Electrodes Improve Brain Readouts” :: PhysOrg.com :: August 12, 2008 :: [ READ ]

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Last updated March 17, 2026